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Article

Genome-wide maps of UVA and UVB mutagenesis in yeast reveal distinct causative lesions and mutational strand asymmetries.

Genetics - 6 Jul 2023

Laughery Marian F, Plummer Dalton A, Wilson Hannah E, Vandenberg Brittany N, Mitchell Debra, Mieczkowski Piotr A, Roberts Steven A, Wyrick John J

Abstract excerpt

Ultraviolet (UV) light primarily causes C > T substitutions in lesion-forming dipyrimidine sequences. However, many of the key driver mutations in melanoma do not fit this canonical UV signature, but are instead caused by T > A, T > C, or C > A substitutions. To what extent exposure to the UVB or UVA spectrum of sunlight can induce these noncanonical mutation classes, and the molecular mechanism involved is...

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Identifiers

PMID: 37170598
DOI: 10.1093/genetics/iyad086
PMCID: PMC10324949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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