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Article

Widespread atypical UV-induced mutations form in single-stranded DNA.

Science advances - 11 Sept 2026

Cordero Cameron, Vandenberg Brittany N, Mittelstadt Isabelle, Murch Jordan, Laughery Marian F, Mieczkowski Piotr A, Wyrick John J, Roberts Steven A

Abstract excerpt

Persistence of common ultraviolet (UV)-induced lesions, like cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6-4) photoproducts (6-4-PPs), typically results in C>T substitutions at dipyrimidines: a mutation pattern that composes the single-base substitution (SBS) signature 7 in cancer. Oncogenic melanoma mutations rarely involve SBS7-like substitutions. We recently identified noncanonical...

Read the complete abstract on PubMed

Topics

Ultraviolet Rays
DNA, Single-Stranded
Mutation
Saccharomyces cerevisiae
DNA Damage
Pyrimidine Dimers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Telomere

DNA Repair

Humans

Saccharomyces cerevisiae Proteins

Excision Repair

Source

Open in PubMed Open full text

Identifiers

PMID: 42726853
DOI: 10.1126/sciadv.aeg5184
PMCID: PMC13564860

Genes

BRAF
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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