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Article

The UVA-induced single-base mutational signature of CX-5461 in human cells.

Nucleic acids research - 24 Aug 2026

Zaikova Elena, Yap Damian, Sarvar Armaghan, Hafezi Auden, Tan Jay, Cerda Viviana, Li Kaylee, Lai Daniel, Gelmon Karen, Hilton John, Seymour Lesley, Stirling Peter, Cescon David W, Aparicio Samuel

Abstract excerpt

Drug-related UVA-induced photoreactions have been reported for several therapeutic compounds, including fluoroquinolones. CX-5461 is a clinical stage quinolone-derived anti-cancer small molecule with documented UVA-sensitizing activity. Here, we compared, by bulk and clonal whole-genome sequencing under extraneous light-protected conditions, the mutational signatures in human retinal pigment epithelial cells...

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Identifiers

PMID: 42639791
DOI: 10.1093/nar/gkag836
PMCID: PMC13504269

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