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Article

A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in Caenorhabditis elegans.

Genetics - 1 Jul 2020

Ye Frank B, Hamza Akil, Singh Tejomayee, Flibotte Stephane, Hieter Philip, O'Neil Nigel J

Abstract excerpt

New anticancer therapeutics require extensive in vivo characterization to identify endogenous and exogenous factors affecting efficacy, to measure toxicity and mutagenicity, and to determine genotypes that result in therapeutic sensitivity or resistance. We used Caenorhabditis elegans as a platform with which to characterize properties of the anticancer therapeutic CX-5461. To understand the processes that...

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Identifiers

PMID: 32414869
DOI: 10.1534/genetics.120.303169
PMCID: PMC7337070

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