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Genotype-Encoded UV Sensitivity in iPSC-Derived Human Melanocytes Reveals MX2 as a Physiological Amplifier of p53/p38-Mediated DNA Damage Signaling

2026-01-23

Abstract excerpt

Ultraviolet (UV) radiation induces DNA damage and oxidative stress in melanocytes, shaping pigmentation phenotypes and elevating photocarcinogenesis risk. Human models that capture donor-specific genetic determinants of UV sensitivity remain limited. Here, we establish a genotype-driven UV response model using induced pluripotent stem cell (iPSC)-derived melanocytes from donors carrying defined MC1R variants. Diff...

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Literature Corpus work: ce0ed6a1-5b72-5bd8-9471-723a0edcd2c5
DOI: 10.20944/preprints202601.1832.v1

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