Article
UV signature mutations.
Photochemistry and photobiology - 1 Jan 2000
Brash Douglas E
Abstract excerpt
Sequencing complete tumor genomes and exomes has sparked the cancer field's interest in mutation signatures for identifying the tumor's carcinogen. This review and meta-analysis discusses signatures and their proper use. We first distinguish between a mutagen's canonical mutations—deviations from a random distribution of base changes to create a pattern typical of that mutagen—and the subset of signature...
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