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Article

Detrimental effects of UV-B radiation in a xeroderma pigmentosum-variant cell line.

Environmental and molecular mutagenesis - 1 Jun 2014

Herman Kimberly N, Toffton Shannon, McCulloch Scott D

Abstract excerpt

DNA polymerase η (pol η), of the Y-family, is well known for its in vitro DNA lesion bypass ability. The most well-characterized lesion bypassed by this polymerase is the cyclobutane pyrimidine dimer (CPD) caused by ultraviolet (UV) light. Historically, cellular and whole-animal models for this area of research have been conducted using UV-C (λ=100-280 nm) owing to its ability to generate large quantities of CPDs...

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Source

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Identifiers

PMID: 24549972
DOI: 10.1002/em.21857
PMCID: PMC4102177

Genes

CPD
POLH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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