Article
Detrimental effects of UV-B radiation in a xeroderma pigmentosum-variant cell line.
Environmental and molecular mutagenesis - 1 Jun 2014
Herman Kimberly N, Toffton Shannon, McCulloch Scott D
Abstract excerpt
DNA polymerase η (pol η), of the Y-family, is well known for its in vitro DNA lesion bypass ability. The most well-characterized lesion bypassed by this polymerase is the cyclobutane pyrimidine dimer (CPD) caused by ultraviolet (UV) light. Historically, cellular and whole-animal models for this area of research have been conducted using UV-C (λ=100-280 nm) owing to its ability to generate large quantities of CPDs...
Topics
- Caffeine
- Cell Proliferation
- Cells, Cultured
- Central Nervous System Stimulants
- DNA Damage
- DNA-Directed DNA Polymerase
- Fibroblasts
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mutagenesis
- Mutation
- Ultraviolet Rays
- Xeroderma Pigmentosum