Article

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

2020-02-01

Abstract excerpt

The ESCRT complexes drive membrane scission in HIV-1 release, autophagosome closure, MVB biogenesis, cytokinesis, and other cell processes. ESCRT-I is the most upstream complex and bridges the system to HIV-1 Gag in virus release. The crystal structure of the headpiece of human ESCRT-I comprising TSG101:VPS28:VPS37B:MVB12A was determined, revealing an ESCRT-I helical assembly with a 12 molecule repeat. Electron mi...

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Literature Corpus work: a721d1ed-d0df-5d81-be71-f4aec8434951
DOI: 10.1101/2020.01.31.927327

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