Article
Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.
Cell - 22 Feb 2018
Su Zhaoming, Wu Chao, Shi Liuqing, Luthra Priya, Pintilie Grigore D, Johnson Britney, Porter Justin R, Ge Peng, Chen Muyuan, Liu Gai, Frederick Thomas E, Binning Jennifer M, Bowman Gregory R, Zhou Z Hong, Basler Christopher F, Gross Michael L, Leung Daisy W, Chiu Wah, Amarasinghe Gaya K
Abstract excerpt
Ebola virus nucleoprotein (eNP) assembles into higher-ordered structures that form the viral nucleocapsid (NC) and serve as the scaffold for viral RNA synthesis. However, molecular insights into the NC assembly process are lacking. Using a hybrid approach, we characterized the NC-like assembly of eNP, identified novel regulatory elements, and described how these elements impact function. We generated a...
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