Article

In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contacts

2022-03-08

Abstract excerpt

VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like mechanism. Direct evidence for this hypothesis from a full-length structure and from EM studies in situ , however, is still missing. Here we have capitalized on AlphaFold predictions to complement the structural information already ava...

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Literature Corpus work: 2a309644-af69-5a26-aa54-e1d0a426bd3d
DOI: 10.1101/2022.03.08.482579

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