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Article

Linker extension impairs ESCRT-III flat spirals and the mediated membrane abscission.

The Journal of cell biology - 6 Apr 2026

Liu Mingdong, Yang Liuyan, Huang Rong, Qi Lei, Song Tiefeng, Huang Yuxuan, Liu Yunhui, Zhang Yu-Zhong, Wang Yong, Shen Qing-Tao

Abstract excerpt

The endosomal sorting complex required for transport III (ESCRT-III) is conserved machinery that drives membrane abscission. While ESCRT-III flat spirals are proposed as a primed state, their essential role and regulation remain unclear. Leveraging our newly resolved architecture of yeast Snf7 flat spirals, we engineered a series of Snf7 mutants by inserting polyglycines into the linker between the helices α4 and...

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PMID: 41556881
DOI: 10.1083/jcb.202503160

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