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Article

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly.

Nature communications - 3 Dec 2015

Caillat Christophe, Macheboeuf Pauline, Wu Yuanfei, McCarthy Andrew A, Boeri-Erba Elisabetta, Effantin Gregory, Göttlinger Heinrich G, Weissenhorn Winfried, Renesto Patricia

Abstract excerpt

The vacuolar protein sorting 4 AAA-ATPase (Vps4) recycles endosomal sorting complexes required for transport (ESCRT-III) polymers from cellular membranes. Here we present a 3.6-Å X-ray structure of ring-shaped Vps4 from Metallosphera sedula (MsVps4), seen as an asymmetric pseudohexamer. Conserved key interface residues are shown to be important for MsVps4 assembly, ATPase activity in vitro, ESCRT-III disassembly...

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Identifiers

PMID: 26632262
DOI: 10.1038/ncomms9781
PMCID: PMC4686814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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