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Article

The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting.

Developmental cell - 1 Jun 2007

Prag Gali, Watson Hadiya, Kim Young C, Beach Bridgette M, Ghirlando Rodolfo, Hummer Gerhard, Bonifacino Juan S, Hurley James H

Abstract excerpt

The yeast Vps27/Hse1 complex and the homologous mammalian Hrs/STAM complex deliver ubiquitinated transmembrane proteins to the ESCRT endosomal-sorting pathway. The Vps27/Hse1 complex directly binds to ubiquitinated transmembrane proteins and recruits both ubiquitin ligases and deubiquitinating enzymes. We have solved the crystal structure of the core responsible for the assembly of the Vps27/Hse1 complex at 3.0 A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

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Source

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Identifiers

PMID: 17543868
DOI: 10.1016/j.devcel.2007.04.013
PMCID: PMC2292400

Genes

STAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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