Article
Structural and functional organization of the ESCRT-I trafficking complex.
Cell - 7 Apr 2006
Kostelansky Michael S, Sun Ji, Lee Sangho, Kim Jaewon, Ghirlando Rodolfo, Hierro Aitor, Emr Scott D, Hurley James H
Abstract excerpt
The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex...
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