Article
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2005
Scott Anna, Gaspar Jason, Stuchell-Brereton Melissa D, Alam Steven L, Skalicky Jack J, Sundquist Wesley I
Abstract excerpt
The VPS4 AAA ATPases function both in endosomal vesicle formation and in the budding of many enveloped RNA viruses, including HIV-1. VPS4 proteins act by binding and catalyzing release of the membrane-associated ESCRT-III protein lattice, thereby allowing multiple rounds of protein sorting and vesicle formation. Here, we report the solution structure of the N-terminal VPS4A microtubule interacting and transport...
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