Article

Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly

2020-11-28

Abstract excerpt

Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many cellular processes including signalling, immunity, neuroprotection and virus infection. To function in different trafficking routes, retromer core (VPS26/VPS29/VPS35) assembles with a range of sorting nexins to generate tubular carriers and incorporate assorted cargoes. We elucidate the structural basis of membrane remodel...

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Literature Corpus work: 39f9bb62-80a4-5fb4-b7e8-29e1c9043e0f
DOI: 10.1101/2020.11.28.401588

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