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Article

Assembly and activation of EBV latent membrane protein 1.

Cell - 5 Sept 2024

Huang Jiafeng, Zhang Xiaolin, Nie Xiaohua, Zhang Xuyuan, Wang Yong, Huang Linlong, Geng Xiaohan, Li Dong, Zhang Liguo, Gao Guangxia, Gao Pu

Abstract excerpt

Latent membrane protein 1 (LMP1) is the primary oncoprotein of Epstein-Barr virus (EBV) and plays versatile roles in the EBV life cycle and pathogenesis. Despite decades of extensive research, the molecular basis for LMP1 folding, assembly, and activation remains unclear. Here, we report cryo-electron microscopy structures of LMP1 in two unexpected assemblies: a symmetric homodimer and a higher-order filamentous...

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Identifiers

PMID: 38996527
DOI: 10.1016/j.cell.2024.06.021

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