Article

Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease

2023-09-17

Abstract excerpt

The effects of genetic variation on complex traits act mainly through changes in gene regulation. Although many genetic variants have been linked to target genes in cis , the trans-regulatory cascade mediating their effects remains largely uncharacterized. Mapping trans-regulators based on natural genetic variation, including eQTL mapping, has been challenging due to small effects. Experimental perturbation appro...

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Literature Corpus work: a4f94380-d76b-5356-95fe-010991347b90
DOI: 10.1101/2023.09.17.557749

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