Article

Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traits

2026-01-05

Abstract excerpt

Most current GWAS-eQTL approaches prioritize genes whose mediating effects on complex traits act through cis-regulation, while trans-acting genes remain largely underexplored. Recent perturbational screening technology provides a novel approach to quantifying trans-effects between gene pairs, but its integration with GWAS data remains largely unexamined. We introduce Mr. PEG, a novel framework that integrates pert...

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Literature Corpus work: 8c334fcd-e20d-596d-a306-f35f6c8657f5
DOI: 10.64898/2026.01.05.26343421

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