Article
Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for twelve immune-mediated diseases
2020-01-15
Abstract excerpt
The identification of causal genetic variants for common diseases improves understanding of disease biology. Here we use data from the BLUEPRINT project to identify regulatory quantitative trait loci (QTL) for three primary human immune cell types and use these to fine-map putative causal variants for twelve immune-mediated diseases. We identify 340 unique, non major histocompatibility complex (MHC) disease loci t...
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Identifiers and source
- Literature Corpus work
- c59611bf-971a-503a-b001-90cc79f71ce0
- DOI
- 10.1101/2020.01.15.907436