Article

Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

2021-04-19

Abstract excerpt

<h4>Summary</h4> Complex gene regulatory networks ensure that important genes are expressed at precise levels. When gene expression is sufficiently perturbed it can lead to disease. To understand how gene expression disruptions percolate through a network, we must first map connections between regulatory genes and their downstream targets. However, we lack comprehensive knowledge of the upstream regulators of mos...

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Literature Corpus work: a995bc6f-0821-57ae-bd0a-cb343653a908
DOI: 10.1101/2021.04.18.440363

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