Article

Population-scale multiome immune cell atlas reveals complex disease drivers

2025-11-27

Abstract excerpt

Most genetic variants associated with complex diseases lie in non-coding regions, yet mechanistic insights have been limited by the lack of an empirical framework for characterizing the molecular consequences of regulatory variation. Single-cell profiling of molecular quantitative trait loci (QTL) can connect variants to gene regulation, but prior studies lacked the sample size to detect variants at disease-releva...

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Literature Corpus work: b748b69a-2eec-5219-88cd-95cbe1caa8b0
DOI: 10.1101/2025.11.25.25340489

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