Article

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cells

2026-03-11

Abstract excerpt

CD4+ T cells harbor a disproportionate enrichment of immune disease risk loci and represent the primary cellular context for immune disease biology, yet the genes and regulatory programs these variants affect remain largely unknown. We combined targeted Perturb-seq of 1,032 cis -regulatory elements (CREs) overlapping 4,724 variants across 14 immune diseases with genome-wide Perturb-seq of all expressed genes in p...

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Literature Corpus work: d0e6e1ba-7f05-5936-b18f-7c5356633cad
DOI: 10.64898/2026.03.09.710372

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