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Article

eIF4A3 Promotes RNA Viruses’ Replication by Inhibiting Innate Immune Responses

31 Oct 2022

Abstract excerpt

Production of type I IFN is pivotal for the cellular antiviral immunity. Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I IFN to eliminate viral infection. Thus, the regulation of IRF3 activity is an important way to affect type I IFN production. IRF3 activation requires phosphorylation, dimerization, and nuclear translocation. Here, we first reported that...

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PMID: 36314820
DOI: 10.1128/jvi.01513-22

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