Article

<i>Fus</i> depleted oligodendrocytes reduce neuronal damage and attenuate AD progression in the App <sup>NL-G-F</sup> mouse

2025-11-26

Abstract excerpt

<h4> Abstract </h4> Oligodendrocytes (OL) and myelin abnormalities have emerged as important contributors to the pathogenesis of Alzheimer’s Disease (AD). OL maintain neuronal health through myelin axon interactions and by supplying neurotrophic and metabolic support. To gain insight on how OL and myelin may improve neuronal deficits associated with AD, we have generated a novel mouse model (AD/cKO) by crossing...

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Literature Corpus work: a480d772-ecb2-5dbb-a823-fecd5c8860c7
DOI: 10.1101/2025.11.24.689041

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