Article

<i>TOMM40</i> suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer’s disease

2025-11-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> While the APOE4 allele is a major risk factor for Alzheimer’s disease (AD), the role of TOMM40 —an adjacent gene involved in mitochondrial protein import—is not known. <h4>METHODS</h4> Mice, human iPSC-derived neurons (iNeurons), and human brain tissue were used for study of animal cognition, cholesterol metabolism, mitochondrial function, and gene expression. <h4>RESU...

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Literature Corpus work: 755a1317-700e-5a0c-b26f-aabc205c5ad5
DOI: 10.1101/2025.10.31.685963

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