Article
Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegeneration
2024-03-08
Abstract excerpt
Microglia, the brain’s primary resident immune cells, are a heterogeneous population and can assume phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, microglia subsets with protective functions have been well characterized. Yet, the identity of microglia subsets that drive neurodegeneration remains unresolved. Here, we ide...
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Identifiers and source
- Literature Corpus work
- f1b115bd-8912-5f30-b99b-87b263dfbe02
- DOI
- 10.1101/2024.03.04.582965