Article

Spatially resolved transcriptome–metabolome integration reveals region-specific glial lipid dysregulation associated with Alzheimer’s pathology

2026-01-25

Abstract excerpt

<h4>Summary</h4> Glial cells maintain the brain’s lipid and energy balance, and their breakdown is increasingly recognized as a causal contributor to Alzheimer’s disease (AD). While this concept is established, no approach has directly shown how glial homeostatic failure manifests across brain regions and microenvironments or how it links local pathology, such as plaques, to global metabolic imbalance. To address...

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Literature Corpus work: 3ca2d5fc-d4c6-5870-9a44-50d22f79b25d
DOI: 10.64898/2026.01.23.701345

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