Article

Early mitochondrial dysfunction proceeds neuroinflammation, synaptic alteration, and autophagy impairment in hippocampus of <i>App</i> knock-in Alzheimer mouse models

2023-03-09

Abstract excerpt

<h4>ABSTRACT</h4> Increased amyloid β-peptide (Aβ) level is one of the drivers of Alzheimer’s disease (AD). Amyloid precursor protein ( App ) knock-in mice recapitulate the human Aβ pathology, allowing the elucidation of the downstream effects of Aβ and their temporal appearance upon disease progression. Here we have investigated the sequential onset of AD-like pathologies in the App NL-F and App NL-G-F knoc...

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Literature Corpus work: d59a1821-aaf8-5e0d-a52e-d57cabea60bc
DOI: 10.1101/2023.03.07.531542

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