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Integrative <i>in situ</i> mapping of single-cell transcriptional states and tissue histopathology in an Alzheimer’s disease model

2022-01-16

Abstract excerpt

Amyloid-β plaques and neurofibrillary tau tangles are the neuropathologic hallmarks of Alzheimer’s disease (AD), but the spatiotemporal cellular responses and molecular mechanisms underlying AD pathophysiology remain poorly understood. Here we introduce STARmap PLUS to simultaneously map single-cell transcriptional states and disease marker proteins in brain tissues of AD mouse models at subcellular resolution (20...

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Literature Corpus work
b52f6ef2-e40a-55c5-abc1-6392caa5e3d3
DOI
10.1101/2022.01.14.476072
Open publication

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Integrative <i>in situ</i> mapping of single-cell transcriptional states and tissue histopathology in an Alzheimer’s disease modelDOI 10.1101/2022.01.14.476072
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