Article

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease

2021-08-02

Abstract excerpt

The prevalence of Alzheimer’s disease (AD), the leading cause of dementia, shows a strict age-dependency, but why ageing constitutes the main risk factor for this disease is still poorly understood. Brain ageing affects oligodendrocytes 1 and the structural integrity of myelin sheaths 2 , the latter associated with secondary neuroinflammation 3 . Since oligodendrocytes support axonal and neuronal health 4–7 ,...

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Literature Corpus work: fb1010fd-4f7c-5573-b640-175e1f9a84f4
DOI: 10.1101/2021.07.31.454562

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