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Article

Human longevity and Alzheimer's disease variants act via microglia and oligodendrocyte gene networks.

Brain : a journal of neurology - 6 Mar 2025

Graham Andrew C, Bellou Eftychia, Harwood Janet C, Yaman Umran, Celikag Meral, Magusali Naciye, Rambarack Naiomi, Botia Juan A, Sala Frigerio Carlo, Hardy John, Escott-Price Valentina, Salih Dervis A

Abstract excerpt

Ageing underlies functional decline of the brain and is the primary risk factor for several neurodegenerative conditions, including Alzheimer's disease (AD). However, the molecular mechanisms that cause functional decline of the brain during ageing, and how these contribute to AD pathogenesis, are not well understood. The objective of this study was to identify biological processes that are altered during ageing...

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Source

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Identifiers

PMID: 39778705
DOI: 10.1093/brain/awae339
PMCID: PMC11884759

Genes

ANKH
CASP8
GRN
ITGAM
LAPTM5
LILRB4
PLEKHA1
SNX1
STAT3
UNC5CL

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