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Article

Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks

9 Jan 2025

Abstract excerpt

Ageing underlies functional decline of the brain and is the primary risk factor for several neurodegenerative conditions, including Alzheimer's disease (AD). However, the molecular mechanisms that cause functional decline of the brain during ageing, and how these contribute to AD pathogenesis, are not well understood. The objective of this study was to identify biological processes that are altered during ageing...

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PMID: 39778705
DOI: 10.1093/brain/awae339

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