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Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimer’s disease

2026-07-13

Abstract excerpt

Alzheimer’s disease (AD) features amyloid-β plaques and tau pathology, yet the mechanism underlying early and clinically significant myelin loss remains unresolved. Here, we report human iPSC-derived forebrain organoids with doxycycline-inducible expression of SOX10, OLIG2, and NKX6-2 (SON), which generate robust, mature oligodendrocytes and compact myelin in vitro and in vivo. Introducing amyloid precursor protei...

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Literature Corpus work
79b309ac-c8d2-590f-9599-4eb2014c6f45
DOI
10.64898/2026.07.08.737318
Open publication

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Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimer’s diseaseDOI 10.64898/2026.07.08.737318
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