Article

Genome-scale requirements for dynein-based trafficking revealed by a high-content arrayed CRISPR screen

2023-03-01

Abstract excerpt

The cytoplasmic dynein-1 (dynein) motor plays a key role in cellular organisation by transporting a wide variety of cellular constituents towards the minus ends of microtubules. However, relatively little is known about how the biosynthesis, assembly and functional diversity of the motor is orchestrated. To address this issue, we have conducted an arrayed CRISPR loss-of-function screen in human cells using the dis...

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Literature Corpus work: a4571359-a69f-5408-af71-cd5ef1fb9eff
DOI: 10.1101/2023.03.01.530592

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