Article

A genome-wide atlas of human cell morphology

2023-08-07

Abstract excerpt

A key challenge of the modern genomics era is developing data-driven representations of gene function. Here, we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing three genome-scale genotype-phenotype maps comprising >20,000 single-gene CRISPR-Cas9-based knockout experiments in >30 million cells. Our optical pooled cell profiling approach (PERISCOPE) combines a de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd9c43a4-72f0-5160-b3a0-fdbe1e041cd3
DOI: 10.1101/2023.08.06.552164

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A genome-wide atlas of human cell morphologyDOI 10.1101/2023.08.06.552164Read

Morphological map of under- and over-expression of genes in human cellsSemantic proximity Read

The phenotypic landscape of essential human genesSemantic proximity Read

The phenotypic landscape of essential human genes.Semantic proximity Read

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seqSemantic proximity Read

Combining NeuroPainting with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletionSemantic proximity Read

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.Semantic proximity Read

High-dimensional phenotyping to define the genetic basis of cellular morphologySemantic proximity Read

Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletionSemantic proximity Read

JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbationsSemantic proximity Read

Cell Painting, an image-based assay for morphological profilingSemantic proximity Read

A Pooled Cell Painting CRISPR Screening Platform Enables de novo Inference of Gene Function by Self-supervised Deep LearningSemantic proximity Read

A global genetic interaction network by single-cell imaging and machine learning.Semantic proximity Read