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Article

Perturbing RNA localization for functional study in neurons

2025-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Spatial RNA organization plays a pivotal role in diverse cellular processes and diseases, but the functional implications of spatial RNA localization remain underexplored. We present CRISPR-mediated transcriptome o rganization (CRISPR-TO) that harnesses RNA-guided, nuclease-dead dCas13 for programmable control of RNA localization in live cells. CRISPR-TO enables targeted localization of RNAs to...

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Literature Corpus work
34c2b839-3002-5091-a02b-2a6835b9d5d7
DOI
10.1101/2025.04.05.646707
Open publication

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Perturbing RNA localization for functional study in neuronsDOI 10.1101/2025.04.05.646707
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