Article

The phenotypic landscape of essential human genes

2021-11-28

Abstract excerpt

Understanding the basis for cellular growth, proliferation, and function requires determining the contributions of essential genes to diverse cellular processes. Here, we combined pooled CRISPR/Cas9-based functional screening of 5,072 fitness-conferring genes in human cells with microscopy-based visualization of DNA, DNA damage, actin, and microtubules. Analysis of >31 million individual cells revealed measurable...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5660993c-5b4e-5e00-946a-b9eb0c37b02e
DOI: 10.1101/2021.11.28.470116

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The phenotypic landscape of essential human genesDOI 10.1101/2021.11.28.470116Read

The phenotypic landscape of essential human genes.Semantic proximity Read

Morphological map of under- and over-expression of genes in human cellsSemantic proximity Read

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Semantic proximity Read

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.Semantic proximity Read

A genome-wide atlas of human cell morphologySemantic proximity Read

A global genetic interaction map of a human cell reveals conserved principles of genetic networksSemantic proximity Read

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seqSemantic proximity Read

Systematic discovery and classification of human cell line essential genesSemantic proximity Read

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.Semantic proximity Read

Contextual diversity of the human cell-essential proteomeSemantic proximity Read

Hierarchical organization of the human cell from a cancer coessentiality networkSemantic proximity Read

Complementary human gene interaction maps from radiation hybrids and CRISPRiSemantic proximity Read