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Article

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility.

The Journal of biological chemistry - 21 Jul 2017

Gutierrez Pedro A, Ackermann Bryce E, Vershinin Michael, McKenney Richard J

Abstract excerpt

Cytoplasmic dynein is the primary minus-end-directed microtubule motor protein in animal cells, performing a wide range of motile activities, including transport of vesicular cargos, mRNAs, viruses, and proteins. Lissencephaly-1 (LIS1) is a highly conserved dynein-regulatory factor that binds directly to the dynein motor domain, uncoupling the enzymatic and mechanical cycles of the motor and stalling dynein on...

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Identifiers

PMID: 28576829
DOI: 10.1074/jbc.M117.790048
PMCID: PMC5519373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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