Article

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

2020-06-27

Abstract excerpt

Single-cell transcriptomics provide a systematic map of gene expression in different human cell types. The next challenge is to systematically understand cell-type specific gene function. The integration of CRISPR-based functional genomics and stem cell technology enables the scalable interrogation of gene function in differentiated human cells. Here, we present the first genomewide CRISPR interference and CRISPR...

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Literature Corpus work: 75a95260-40e2-5248-94e1-f830b72fee61
DOI: 10.1101/2020.06.27.175679

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