Article

Cortical free-water imaging in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants

2026-05-25

Abstract excerpt

<title>Abstract</title> Background Familial frontotemporal lobar degeneration (FTLD) caused by pathogenic variants in C9orf72, GRN, and MAPT provides a unique framework for evaluating imaging markers of genotype-specific neurodegeneration. Conventional cortical mean diffusivity (cMD) is sensitive to microstructural injury but is influenced by extracellular free-water effects. We investigated whether cortical...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a45430ba-f304-5813-8406-28e958b44aba
DOI: 10.21203/rs.3.rs-9677636/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cortical free-water imaging in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variantsDOI 10.21203/rs.3.rs-9677636/v1Read

Cortical microstructure in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants: Looking beyond atrophy.Semantic proximity Read

MRI-based classifier to identify close-to-onset cases in C9orf72 genetic frontotemporal dementiaSemantic proximity Read

White matter microstructure alterations in frontotemporal dementia: Phenotype-associated signatures and single-subject interpretation.Semantic proximity Read

White Matter Hyperintensities Precede other Biomarkers in GRN Frontotemporal DementiaSemantic proximity Read

Gray and white matter changes in presymptomatic genetic frontotemporal dementia: a longitudinal MRI studySemantic proximity Read

White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohortSemantic proximity Read

Investigating the Role of Neuroinflammation and Brain Clearance in Frontotemporal Lobar Degeneration using 7T MRI and Biofluid Markers: Protocol for an observational cross-sectional cohort studySemantic proximity Read

Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia.Semantic proximity Read

Neurite-based white matter alterations in MAPT mutation carriers: A multi-shell diffusion MRI study in the ALLFTD consortium.Semantic proximity Read

Structural Brain Changes in Pre-Clinical FTD MAPT Mutation Carriers.Semantic proximity Read

Neurite density is reduced in the presymptomatic phase ofC9orf72diseaseSemantic proximity Read

Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differencesSemantic proximity Read