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Article

Neurite density is reduced in the presymptomatic phase ofC9orf72disease

24 Oct 2018

Abstract excerpt

Objective To assess the added value of neurite orientation dispersion and density imaging (NODDI) compared with conventional diffusion tensor imaging (DTI) and anatomical MRI to detect changes in presymptomatic carriers of chromosome 9 open reading frame 72 (C9orf72) mutation. Methods The PREV-DEMALS (Predict to Prevent Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis) study is a prospective,...

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PMID: 30355607
DOI: 10.1136/jnnp-2018-318994

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