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Article

Glymphatic dysfunction, plasma neurofilament light, and cortical free water mediate cognitive decline in familial frontotemporal lobar degeneration.

The journal of prevention of Alzheimer's disease - 1 Oct 2026

Qiu Meiling, Ding Li, Bao Rui, Gong Juanyu, Ding Wencai, Shao Zhiding, Han Yongsheng

Abstract excerpt

BACKGROUND: Familial frontotemporal lobar degeneration (f-FTLD) is the second most common form of young-onset dementia, with diverse clinical presentations, neuropathological substrates and genetic backgrounds. While evidence suggests that glymphatic dysfunction, neuroaxonal injury, and cortical microstructural alterations may jointly contribute to f-FTLD, their interrelationships across genotypes remain unclear....

Read the complete abstract on PubMed

Topics

Humans
Neurofilament Proteins
Diffusion Tensor Imaging
Female
Frontotemporal Lobar Degeneration
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Glymphatic System

Cognitive Dysfunction

C9orf72 Protein

tau Proteins

Progranulins

Aged

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42401160
DOI: 10.1016/j.tjpad.2026.100639
PMCID: PMC13348048

Genes

GRN
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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