Article

MRI-based classifier to identify close-to-onset cases in <i>C9orf72</i> genetic frontotemporal dementia

2025-10-20

Abstract excerpt

Predicting symptom onset in genetic frontotemporal dementia (FTD) is crucial for advancing targeted interventions and clinical trial design. Brain changes begin years before clinical symptoms emerge, making neuroimaging a strong candidate for onset prediction. However, FTD is highly heterogeneous, encompassing diverse molecular pathologies, affected brain networks, and symptom trajectories. This variability limits...

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Literature Corpus work: f19bc77b-eb94-5e41-a09b-08b5299230ae
DOI: 10.1101/2025.10.18.683237

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