Article
Structural Brain Changes in Pre-Clinical FTD MAPT Mutation Carriers.
Journal of Alzheimer's disease : JAD - 1 Jan 2020
Domínguez-Vivero Clara, Wu Liwen, Lee Seonjoo, Manoochehri Masood, Cines Sarah, Brickman Adam M, Rizvi Batool, Chesebro Anthony, Gazes Yunglin, Fallon Emer, Lynch Timothy, Heidebrink Judith L, Paulson Henry, Goldman Jill S, Huey Edward, Cosentino Stephanie
Abstract excerpt
BACKGROUND: Frontotemporal dementia (FTD) is the second most common cause of early-onset neurodegenerative dementia. Several studies have focused on early imaging changes in FTD patients, but once subjects meet full criteria for FTD diagnosis, structural changes are generally widespread. OBJECTIVE: This study aims to determine the earliest structural brain changes in asymptomatic MAPT MUTATION carriers. METHODS:...
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