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Article

Gray and white matter changes in presymptomatic genetic frontotemporal dementia: a longitudinal MRI study

8 Jan 2019

Abstract excerpt

In genetic frontotemporal dementia, cross-sectional studies have identified profiles of presymptomatic neuroanatomical loss for C9orf72 repeat expansion, MAPT, and GRN mutations. In this study, we characterize longitudinal gray matter (GM) and white matter (WM) brain changes in presymptomatic frontotemporal dementia. We included healthy carriers of C9orf72 repeat expansion (n = 12), MAPT (n = 15), GRN (n = 33)...

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PMID: 30711674
DOI: 10.1016/j.neurobiolaging.2018.12.017

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