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Article

Cortical microstructure in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants: Looking beyond atrophy.

The journal of prevention of Alzheimer's disease - 1 Dec 2025

Wang Lijuan, Cen Si, Zhao Li, Tang Junfeng, Xu Pengcheng, Quan Pusheng, Ding Wencai

Abstract excerpt

BACKGROUND: This study aimed to evaluate cortical mean diffusivity (cMD) as a sensitive biomarker for early neurodegenerative changes in familial frontotemporal lobar degeneration (FTLD) associated with C9orf72, GRN, and MAPT mutations. We compared cMD with cortical thickness (cTH) in detecting subtle microstructural alterations and examined its association with clinical severity and neurofilament light chain...

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Identifiers

PMID: 40701902
DOI: 10.1016/j.tjpad.2025.100306
PMCID: PMC12627885

Genes

GRN
MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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