Neurite-based white matter alterations in MAPT mutation carriers: A multi-shell diffusion MRI study in the ALLFTD consortium.

doi:10.1016/j.neurobiolaging.2023.12.001

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Article

Neurite-based white matter alterations in MAPT mutation carriers: A multi-shell diffusion MRI study in the ALLFTD consortium.

Neurobiology of aging - 1 Feb 2024

Corriveau-Lecavalier Nick, Tosakulwong Nirubol, Lesnick Timothy G, Fought Angela J, Reid Robert I, Schwarz Christopher G, Senjem Matthew L, Jack Clifford R, Jones David T, Vemuri Prashanthi, Rademakers Rosa, Ramos Eliana Marisa, Geschwind Daniel H, Knopman David S, Botha Hugo, Savica Rodolfo, Graff-Radford Jonathan, Ramanan Vijay K, Fields Julie A, Graff-Radford Neill, Wszolek Zbigniew, Forsberg Leah K, Petersen Ronald C, Heuer Hilary W, Boxer Adam L, Rosen Howard J, Boeve Bradley F, Kantarci Kejal

Abstract excerpt

We assessed white matter (WM) integrity in MAPT mutation carriers (16 asymptomatic, 5 symptomatic) compared to 31 non-carrier family controls using diffusion tensor imaging (DTI) (fractional anisotropy; FA, mean diffusivity; MD) and neurite orientation dispersion and density imaging (NODDI) (neurite density index; NDI, orientation and dispersion index; ODI). Linear mixed-effects models accounting for age and...

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Identifiers

PMID: 38091751
DOI: 10.1016/j.neurobiolaging.2023.12.001
PMCID: PMC10872472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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