Article
Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia.
Neurology - 26 Feb 2013
Dopper Elise G P, Rombouts Serge A R B, Jiskoot Lize C, Heijer Tom den, de Graaf J Roos A, Koning Inge de, Hammerschlag Anke R, Seelaar Harro, Seeley William W, Veer Ilya M, van Buchem Mark A, Rizzu Patrizia, van Swieten John C
Abstract excerpt
OBJECTIVE: We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of microtubule-associated protein tau and progranulin mutations. METHODS: In this case-control study, 75 healthy individuals (aged 20-70 years) with 50% risk for frontotemporal dementia (FTD) underwent DNA screening, neuropsychological...
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