Article

Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelination

2025-08-24

Abstract excerpt

<h4>Summary</h4> The extensive heterogeneity of microglia inflammatory states accompanying neurodegenerative diseases underscores the complex molecular mechanisms that regulate these cells. Here, we report on transcriptional mechanisms that control microglial inflammatory polarization associated with brain demyelination in mice. Using flow cytometry, microscopy and RNA-seq, we identified two dominant, functionall...

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Literature Corpus work: c88837ec-38c7-540f-9c47-f3da0cf6bdd8
DOI: 10.1101/2025.08.21.670551

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