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Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived Microglia

2024-10-16

Abstract excerpt

<title>Abstract</title> <p>Background Substantial evidence has established the critical role of microglia, the brain's resident immune cells, in the pathogenesis of Alzheimer's disease (AD). Microglia exhibit diverse transcriptional states in response to neuroinflammatory stimuli, and understanding these states is crucial for elucidating the underlying mechanisms of AD. Methods In this work, we integrated singl...

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Literature Corpus work
0bebf46c-61c8-57e1-875c-89cb65744056
DOI
10.21203/rs.3.rs-5045715/v1
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Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived MicrogliaDOI 10.21203/rs.3.rs-5045715/v1
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